The short answer: It’s a tie — both formulas score B (75/100) — and they share a parent company (Mars Petcare). Eukanuba positions higher in the premium/performance shelf and uses a cleaner grain stack (no sorghum, wheat instead of corn + sorghum). Iams is the budget sister brand with wider retail distribution. For most puppy households, the call comes down to price and where you shop.

The scores

Eukanuba Puppy Medium Breed Chicken: B (75/100) — Very Good. Named chicken first, chicken by-product meal second, and a grain stack of corn + wheat + corn grits. Engineered around the 3D DNA research program Mars runs for Eukanuba.

Iams ProActive Health Smart Puppy Original with Chicken: B (75/100) — Very Good. Named chicken first, then ground whole grain corn, chicken by-product meal, and a grain stack of corn + sorghum + beet pulp. Mars’s value-tier puppy formulation.

How the ingredients compare

The top five ingredients:

Eukanuba Puppy Medium: Chicken, Chicken By-Product Meal, Corn, Chicken Fat, Wheat

Iams Smart Puppy: Chicken, Ground Whole Grain Corn, Chicken By-Product Meal, Ground Whole Grain Sorghum, Dried Plain Beet Pulp

Both formulas open with fresh chicken and use chicken by-product meal as a core protein contributor — an intentional Mars formulation choice that delivers organ-meat density at value-tier cost. By-product meal is AAFCO-defined as clean, rendered parts of the carcass excluding feathers, hair, horn, teeth, hooves, and digestive-tract contents. Nutritionally it’s dense in bioavailable nutrients, though the name is off-putting to many consumers.

The structural difference is in the grain stack. Eukanuba puts corn in position three and wheat in position five, with chicken fat wedged into position four — a higher-protein, higher-fat macro profile suited for a medium-breed puppy’s metabolic demands. Iams puts corn in position two (right after the fresh chicken), then by-product meal in three, sorghum in four, and beet pulp in five — a more carbohydrate-heavy opening suited for the broader mainstream-puppy market where Iams plays.

Further down, Eukanuba adds corn grits, chicken flavor, fish oil, flaxseed, dried beet pulp, an extensive vitamin/mineral premix, and the 3D DENTADEFENSE (proprietary dental additive) + DHA package. Iams adds chicken fat, egg product, natural flavor, fish oil, flaxseed, and a DHA + prebiotic-fiber premix. Both hit the puppy-nutrition fundamentals — DHA from fish oil for brain development, appropriate calcium:phosphorus, prebiotics (beet pulp) for sensitive puppy digestion.

Where Eukanuba Puppy pulls ahead

Higher protein + fat macro profile: Eukanuba Puppy Medium delivers 30% protein / 20% fat minimums, notably above Iams Smart Puppy’s 28% protein / 17% fat. For working-breed puppies and more active medium-breed households, the higher energy density matches metabolic demand better.

Chicken fat in position four: Fat in the top five means energy-dense macronutrients lead the formula — appropriate for a puppy’s growth energy requirements. Iams delays chicken fat deeper into the ingredient list.

DENTADEFENSE dental package: Eukanuba adds a proprietary dental-plaque-reducing additive (often sodium hexametaphosphate or a kibble-texture design) that Iams doesn’t include. Modest benefit, but worth mentioning. Shop on Amazon →

Where Iams Puppy holds its own

Price per pound: Iams Smart Puppy is materially cheaper than Eukanuba on retail channels — often 25–35% less at Walmart, Target, Amazon, and most grocery chains. For owners of larger litters, foster puppies, or rescue-group feeding programs, the budget delta compounds fast.

Wider retail distribution: Iams is stocked at virtually every grocery store, big-box retailer, and pet specialty store in North America. Eukanuba’s distribution skews to pet specialty and breeder channels — harder to find in a pinch.

Sorghum + beet pulp fiber architecture: Sorghum is lower on the glycemic index than corn, and beet pulp is a well-tolerated prebiotic fiber that supports sensitive puppy stomachs. Iams’s choice here isn’t accidental — the Smart Puppy line targets the mainstream-owner buyer whose biggest feeding anxiety is inconsistent stools. Shop on Amazon →

The bottom line

For an active medium-breed puppy or a working-breed household, Eukanuba Puppy Medium Breed is the slightly more performance-oriented pick at a modest premium. For the budget-conscious household or anyone already buying Iams from a grocery run, Iams Smart Puppy delivers the same score at a lower sticker price with wider availability. Both are Mars Petcare formulations made in the same quality-control ecosystem, and the one-brand-vs-the-other decision is mostly about shelf positioning and marketing target. See our best affordable dog food guide for a broader comparison.